Association Between the Chromosome 9p21 Locus and Angiographic Coronary Artery Disease Burden
نویسندگان
چکیده
منابع مشابه
The chromosome 9p21 risk locus is associated with angiographic severity and progression of coronary artery disease.
AIMS we tested the hypothesis that the 9p21 risk locus promotes atherosclerosis by examining the association between rs10757278 and coronary artery disease (CAD) severity and progression determined by semi-quantitative angiographic scores. METHODS AND RESULTS the rs10757278 single nucleotide polymorphism (SNP) was genotyped as the marker for the 9p21 locus in 2334 Caucasian patients undergoin...
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Background: Coronary artery disease (CAD) is a multifactorial and heterogenic disease. Recently, genome-wide association studies have reported that rs1333040 (C/T) and rs1004638 (A/T) single nucleotide polymorphisms (SNPs) in the 9p21 locus have very strong association with CAD. This study aimed to examine these associations in Southwest of Iran. Methods: Blood samples were collected from 200 C...
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BACKGROUND A chromosome 9p21 locus is associated with coronary heart disease in 25 independent populations, but multiple clinically distinct phenotypes have been evaluated. Using angiographic coronary artery disease (CAD) phenotyping, this study evaluated whether 9p21 single-nucleotide polymorphisms predict ischemic events (eg, myocardial infarction [MI]) among CAD patients. METHODS AND RESUL...
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متن کاملCoronary artery disease-associated locus on chromosome 9p21 and early markers of atherosclerosis.
BACKGROUND Genome-wide association studies have recently identified a locus on chromosome 9p21 that influences risk of coronary artery disease (CAD). The effect of the locus on early markers of atherosclerosis is unknown. We examined its association with carotid intima-media thickness (CIMT) and brachial flow-mediated dilatation (FMD). METHODS AND RESULTS We genotyped 2277 individuals, age 24...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2013
ISSN: 0735-1097
DOI: 10.1016/j.jacc.2012.10.051